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Human Reproduction, Vol. 3, No. suppl_2, pp. 35-38, 1988
© 1988 European Society of Human Reproduction and Embryology

Addition of Buserelin to human menopausal gonadotrophins in patients with failed stimulations for IVF or GIFT

J. Smitz, P. Devroey, M. Camus, I. Khan, C. Staessen, L. Van Waesberghe, A. Wisanto and A.C. Van Steirteghem

Centre for Reproductive Medicine, Akademisch Ziekenhuis, Vrije Universiteit Brussel Laarbeeklaan, 101, B-1090, Brussels, Belgium

The combined therapy of a gonadotrophin-releasing hormone agonist (GnRH) D-Ser(TBU)6-EA10-LHRH (Buserelin) and human menopausal gonadotrophins (HMG) for ovarian stimulation for in-vitro fertilization and gamete intra-Fallopian transfer was evaluated during 84 cycles. All women selected for this therapy had previously failed stimulations with clomiphene citrate/HMG. The GnRHa prevented spontaneous luteinizing hormone surges and premature luteinization in all patients. After addition of the agonist to HMG, the cancellation rate dropped from 17 to 7% and improved the results in 72.6% of the cycles. Twenty-six per cent of the started cycles resulted in a pregnancy. Eighteen healthy children were born at term.

Key words: GnRH agonist/IVF/GIFT/luteal phase

Submitted on June 13, 1988;
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