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Human Reproduction, Vol. 3, No. suppl_2, pp. 85-87, 1988
© 1988 European Society of Human Reproduction and Embryology

Embryo donation in patients with primary ovarian failure

P. Devroey, P. Braeckmans, M. Camus, I. Khan, J. Smitz, C. Staessen, E. Van den Abbeel, L. Van Waesberghe, A. Wisanto and A.C. Van Steirteghem

Centre for Reproductive Medicine, Academic Hospital and Medical Campus, Vrije Universiteit Brussel Laarbeeklaan 101, B-1090 Brussels, Belgium

Thirty-six infertile patients with primary ovarian failure, who were referred for oocyte (embryo) donation are reported. After substitution therapy with oestradiol valerate (per os) and progesterone (i.m. or per os), endometrial tissue was made receptive for embryonic implantation, although the endometrial biopsies on day 21 demonstrated a certain delay in development (of 1.6–2.4 days). Six patients became pregnant, three of them delivered four healthy babies, one pregnancy is progressing normally and two ended in an early clinical abortion.

Key words: primary ovarian failure/embryo donation/oestra-diol/progesterone

Submitted on April 14, 1988;
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