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Human Reproduction, Vol. 4, No. 6, pp. 625-628, 1989
© 1989 European Society of Human Reproduction and Embryology

other

Salivary oestradiol in spontaneous and stimulated menstrual cycles

J. Berthonneau1, G. Tanguy2, Y. Janssens, A. Guichard, P. Boyer, J.-R. Zorn and L. Cedard

2Unité INSERM 166, Centre de Fécondation In Vitro Baudelocque, Saint-Vincent-de-Paul, 123 Boulevard de Port-Royal 75014, Paris, France Laboratoire de Biologie de la Reproduction, Service de Gynécologie Obstétrique, Hopital Jean-Bernard 86021 Poitiers, France

Correspondence: 1To whom correspondence should be addressed

The determination of steroids in saliva provides useful information in the clinical study of various endocrine functions, and salivary progesterone concentration has been widely used for assessing corpus luteum function during the spontaneous menstrual cycle and early pregnancy. However, the determination of oestradiol in saliva (SE2) has previously been found unsatisfactory. SE2 profiles and saliva/plasma E2 ratios were established (during the different periods of the menstrual cycle) by a highly sensitive radioimmunoassay method during normal menstrual cycle. During cycles hyperstimulated for in-vitro fertilization and embryo transfer, the SE2 pattern is similar to the corresponding profile in plasma with a peri-ovulatory oestradiol peak. There is a significant difference between fertile and non-fertile cycles with a higher saliva/plasma ratio in conception cycles.

Key words: saliva/oestradiol/menstrual cycle/ovarian stimulation/IVF-embryo transfer


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