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Human Reproduction, Vol. 4, No. 6, pp. 647-650, 1989
© 1989 European Society of Human Reproduction and Embryology


other

Follicle-stimulating hormone as a prognostic indicator in clomiphene citrate/human menopausal gonadotrophin-stimulated cycles for in-vitro fertilization

T. Tanbo, P.O. Dale, T. Åbyholm and K.T. Stokke1

1Department of Clinical Chemistry, The National Hospital, University of Oslo Oslo, Norway Department of Obstetrics and Gynaecology, The National Hospital, University of Oslo Oslo, Norway

Follicle-stimulating hormone (FSH), luteinizing hormone (LH), oestradiol and prolactin levels were studied in a sequential clomiphene citrate/human menopausal gonadotrophin (CC/HMG) regimen for in-vitro fertilization. At completion of CC administration, the median FSH level in 44 cancelled cycles was elevated compared to a control group of 65 completed cycles, 29 IU/I versus 15 IU/I, P< 0.01. Also the median FSH/LH ratio was higher in the cancelled cycles than in the control group, 1.08 versus 0.71, P< 0.05. Conversely, the median oestradiol level was lower in the cancelled cycles than in the completed cycles, 0.27 nmol/I versus 0.59 nmol/I, P< 0.01. No difference was seen in the 95%confidence limit was found in 24 of the cancelled cycles, but in only two of the completed cycles. Based on this study, an elevated FSH value following CC administration predicts a poor response to further stimulation with an accuracy of 92.3% and should result in cancellation of the cycle.

Key words: clomiphene citrate/FSH/HMG/IVF


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