Human Reproduction, Vol. 4, No. 6, pp. 647-650, 1989
© 1989 European Society of Human Reproduction and Embryology
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Follicle-stimulating hormone as a prognostic indicator in clomiphene citrate/human menopausal gonadotrophin-stimulated cycles for in-vitro fertilization
1Department of Clinical Chemistry, The National Hospital, University of Oslo Oslo, Norway Department of Obstetrics and Gynaecology, The National Hospital, University of Oslo Oslo, Norway
Follicle-stimulating hormone (FSH), luteinizing hormone (LH), oestradiol and prolactin levels were studied in a sequential clomiphene citrate/human menopausal gonadotrophin (CC/HMG) regimen for in-vitro fertilization. At completion of CC administration, the median FSH level in 44 cancelled cycles was elevated compared to a control group of 65 completed cycles, 29 IU/I versus 15 IU/I, P< 0.01. Also the median FSH/LH ratio was higher in the cancelled cycles than in the control group, 1.08 versus 0.71, P< 0.05. Conversely, the median oestradiol level was lower in the cancelled cycles than in the completed cycles, 0.27 nmol/I versus 0.59 nmol/I, P< 0.01. No difference was seen in the 95%confidence limit was found in 24 of the cancelled cycles, but in only two of the completed cycles. Based on this study, an elevated FSH value following CC administration predicts a poor response to further stimulation with an accuracy of 92.3% and should result in cancellation of the cycle.
Key words: clomiphene citrate/FSH/HMG/IVF
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