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Human Reproduction, Vol. 4, No. suppl_1, pp. 83-86, 1989
© 1989 European Society of Human Reproduction and Embryology

A new variation of in-vitro fertilization: intravaginal culture of human oocytes and cleavage stages

K. Sterzik1, B. Rosenbusch, V. Sasse, A. Wolf, H. M. Beier2 and C. Lauritzen

Department of Obstetrics and Gynaecology, Medical Faculty, University of Ulm D-7900 Ulm 2 Department of Anatomy and Reproductive Biology, Medical Faculty RWTH Aachen, D-5100 Aachen, FRG

Correspondence: 1To whom correspondence should be addressed

In this study, we present further experiences with the intravaginal culture (IVC) of oocytes and cleavage stages. IVC is a new technique for in-vitro fertilization, its principle consisting of fertilization of oocytes in an air-free plastic capsule which is placed into the maternal vagina. In a total of 45 patients, 22 were treated by IVC and 23 by a conventional in-vitro fertilization technique (IVF). The pregnancy rates for IVC and IVF amounted to 22.7% (5/22) and 17.4% (4/23), respectively. Our results indicate that IVC is a valuable new method for treatment of special cases of sterility. Furthermore, extracorporal stress factors such as light and low temperature can be minimized by IVC. We also consider the psychological factor for the patients as very important since the mother can actively participate in the early development of the conceptus.

Key words: human cleavage stages/human oocytes/intravaginal culture/in-vitro fertilization/psychological factors in IVF


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