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Human Reproduction, Vol. 5, No. 1, pp. 19-24, 1990
© 1990 European Society of Human Reproduction and Embryology

research-article

Adrenoceptors mediating contraction in the human uterine artery

M. Stjernquist1 and Ch. Owman2

Department of Obstetrics and Gynaecology at Malmo, University of Lund, General Hospital S-214 01 Malmö 2Department of Medical Cell Research, University of Lund Biskopsgatan 5, S-223 62 Lund, Sweden

Correspondence: 1To whom correspondence should be addressed

Pharmacological characterization of adrenoceptors mediating smooth muscle contraction was performed in isolated preparations from the human uterine artery. The mixed {alpha}1 and {alpha}2-adrenergic agonist, noradrenaline (NA) and the selective {alpha}1-agonists, phenylephrine and methoxamine, all contracted the smooth muscle preparations in a concentration-dependent manner. The responses were antagonized competitively by the selective {alpha}1-antagonist, prazosin, yielding pA2 values for the three agonists (8.33–9.08) typical for an interaction with {alpha}1-receptors. The {alpha}2-selective receptor agonists, clonidine and BHT 920, did not exert any contractile effects in the isolated uterine arteries, and the {alpha}2-adrenergic antagonist, yohimbine, counteracted the contractile effect of NA only at high concentrations. The concentration-response curve for NA was unaffected by the {alpha}2-selective antagonists, rauwolscine and idazoxan. The results suggest that the postjunctional contractile receptors in the human uterine artery primarily are of the {alpha}1 type, and give no evidence for any substantial involvement of {alpha}2-receptors in this important tributary vessel of the human female reproductive tract.

Key words: adrenoceptors/noradrenaline/uterine artery/vascular/smooth muscle


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