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Human Reproduction, Vol. 5, No. 1, pp. 36-39, 1990
© 1990 European Society of Human Reproduction and Embryology

research-article

Treatment of hyperstimulation during in-vitro fertilization

J. Salat-Baroux, S. Alvarez, J.M. Antoine, D. Cornet, Ch. Tibi, M. Plachot1 and J. Mandelbaum1

Department of Obstetrics and Gynaecology, Hopital Tenon, University Paris VI 4 Rue de la Chine, 75020 Paris 1Unité 173, INSERM, Hopital Necker Paris, France

In 33 patients treated with a combination of an LHRH agonist (LHRH-A) and gonadotrophin in a long protocol, a biological hyperstimulation occurred (E2 > 2500 pg/ml on the day of HCG administration and 4722 ± 1190 pg/ml the day after, with > 10 follicles > 12 mm on each ovary). The replacement of fresh embryos were deferred and LHRH-A was continued, and an endometrial biopsy was performed on the theoretical day of replacement (2 days after oocyte recovery). With this technique, we obtained a mean number of 17.9 ± 7 oocytes, a fertilization rate of 49% and a replacement rate of 87% in a deferred cycles. The overall pregnancy rate of frozen-thawed embryos was 27% in the seven spontaneous cycles, 12 induced cycles and 10 artificial cycles. Only one severe hyperstimulation occurred and this case emphasizes that caution remains necessary even with this technique.

Key words: In-vitro fertilization/hyperstimulation/polycystic/ovary disease/LHRH agonists/transfer after freezing embryos


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T. Al-Shawaf, A. Zosmer, S. Hussain, A. Tozer, N. Panay, C. Wilson, A.M. Lower, and J.G. Grudzinskas
Prevention of severe ovarian hyperstimulation syndrome in IVF with or without ICSI and embryo transfer: a modified `coasting' strategy based on ultrasound for identification of high-risk patients
Hum. Reprod., January 1, 2001; 16(1): 24 - 30.
[Abstract] [Full Text] [PDF]


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