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Human Reproduction, Vol. 5, No. 1, pp. 43-46, 1990
© 1990 European Society of Human Reproduction and Embryology

research-article

Antiphospholipid antibodies in unselected patients with repeated abortion

J. Balasch1, J. Font2, A. L{odot}pez-Soto2, R. Cervera2, I. Jové, F.J. Casals2 and J.A. Vanrell

Departments of Obstetrics and Gynaecology c/Casanova, 143, 08036 Barcelona, Spain 2Internal Medicine, Faculty of Medicine, Hospital Clinic i Provincial c/Casanova, 143, 08036 Barcelona, Spain

Correspondence: 1To whom correspondence should be addressed

We have studied, prospectively, the incidence of several antiphospholipid antibodies (lupus anticoagulant, anti-cardiolipin, anti-phosphatidylserine, anti-phosphatidic acid, anti-phosphatidylinositol and anti-thromboplastin antibodies) in 65 consecutive patients with two or more (range 2-8, mean 3.1) abortions. Lupus anticoagulant activity was detected in seven (10.7%) patients and all of them exhibited other antiphospholipid antibodies. Of the previous pregnancies in these seven women, 88% had ended in spontaneous abortion. Four of them achieved pregnancy after low-dose aspirin therapy was started, and carried successfully to term. It is concluded that antiphospholipid antibodies, namely lupus anticoagulant, should be routinely screened in the recurrent spontaneous aborter.

Key words: abortion/autoimmunity/antiphospholipid antibodies/lupus anticoagulant/aspirin


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