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Human Reproduction, Vol. 5, No. 1, pp. 60-65, 1990
© 1990 European Society of Human Reproduction and Embryology

research-article

Transfers of frozen—thawed human embryos in cycles stimulated by HMG

J. Lornage, D. Boulieu1, C. Mathieu, J.F. Guerin, M.C. Pinatel, R. James1 and C. Alvarado

Laboratoire de Biologie de la Reproduction et du Développement Place d'Arsonval, 69437 Lyon Cedex 03, France 1Clinique de Gynécologic L'H6pital Edouard Herriot Place d'Arsonval, 69437 Lyon Cedex 03, France

A total of 130 transfers of frozen-thawed (F-T) human embryos was carried out after moderate ovarian stimulation with human menopausal gonadotrophin (HMG). Embryos were replaced 3 days after the spontaneous luteinizing hormone (LH) surge or 4 days if ovulation was induced by human chorionic gonadotrophin (HCG). Embryos were thawed a few hours prior to transfer. One-hundred-and-twenty-three transfers were effective and 23 pregnancies were achieved. The rate of ongoing pregnancies per transfer was 17.9% (22/123). The survival rate of embryos originating from cycles stimulated by a combination of an LHRH analogue and HMG in a long protocol (LA-HMG protocol) was significantly lower when compared with the rate of embryos retrieved from clomiphene citrate-HMG (CC-HMG protocol) stimulated cycles (52 versus 67%, P > 0.05). When fresh embryos originated from cycles stimulated with an LHRH analogue and HMG in a short protocol (SA-HMG protocol), the survival rate was not affected (59 versus 67%, NS). Although the difference was not significant, the ongoing pregnancy rate per transfer according to the three protocols from which the embryos originated seemed to be better with the SA-HMG protocol: 16% with the CC-HMG protocol, 14.5% with the LA-HMG protocol versus 27.6% with the SA-HMG protocol The success rate was independent of the number of F-T transferred embryos if at least one embryo with 100% intact blastomeres was replaced.

Key words: cryopreservation/human embryo quality/LHRH/analogue


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