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Human Reproduction, Vol. 5, No. 3, pp. 237-241, 1990
© 1990 European Society of Human Reproduction and Embryology

research-article

The impact of peritoneal trauma on intra-abdominal fibrinolytic activity, adhesion formation and early embryonic development in a rabbit longitudinal model

P. X. J. M. Bouckaert1, J. A. Land, E. J. P. Brommer2, J. J. Emeis2 and J. L. H. Evers

Department of Obstetrics and Gynaecology University Hospital PO Box 1918, NL–6201 BX Maastricht 2Gaubius Institute TNO Research Centrefor Fibrinolysis and Thrombolyis Herenstraat 5d NL–2313 AD Leiden The Netherlands

Correspondence: 1To whom correspondence should be addressed

Intra-abdominal adhesions may interfere with fertility following gynaecological surgery and injury to the peritoneum plays a central role in the pathogenesis. Tissue plasminogen activator and its antagonists play a pivotal role in the intra-abdominal balance between fibrinolysis and adhesion formation. This process may be cycle-dependent in women. In order to establish the impact of the fibrinolytic activity on adhesion formation after a standardized trauma, a rabbit longitudinal model was developed, which allowed the study of possible differences between the periods before and after ovulation. The influence of extra-genital adhesions on early embryonic development was investigated. No cycle-dependent changes in fibrinolytic activity of the peritoneal fluid (PF) or of the serum could be demonstrated. No correlation was found between post-operative adhesion formation and the fibrinolytic activity during surgery. Three weeks after surgery, a significant increase in fibrinolytic activity of the PF was observed. The rank order of sampling is suggested to account for these differences. Extra-genital adhesions did not markedly influence ovulation, ovum pick-up and fertilization in this hormonally controlled rabbit model.

Key words: adhesions/embryo/fibrinolysis/peritoneum/trauma


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