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Human Reproduction, Vol. 5, No. 3, pp. 255-257, 1990
© 1990 European Society of Human Reproduction and Embryology

research-article

The response to ovarian hyperstimulation and in-vitro fertilization in women older than 35 years

Shimon Segal1 and Robert F. Casper2

Division of Reproductive Sciences Department of Obstetrics and Gynaecology The University of Toronto Toronto Canada 1Dr Segal is a visiting clinical research fellow from Hillel Jaffee Medical Centre Hadera Israel

Correspondence: 2To whom correspondence should be addressed at: 6–240 EN, Toronto General Hospital, 200 Elizabeth St, Toronto, Ontario, Canada M5G 2C4

There are conflicting reports concerning the effect of female age and potential reproductive function. We assessed the response to ovarian hyperstimulation in two consecutive FVF cycles in 25 women >35 years of age and compared their response to a control group of 48 women <35 years of age who conceived in our IVF programme. In the older women, the maximal oestradiol response was proportional to the number of vials of HMG used and did not differ from the response of the younger women. Similarly, the number of follicles of diameter >1.0 cm, the number of oocytes recovered and the number of embryos which cleaved did not differ between the older and the younger women. However, conception rates were markedly lower in the older women than the overall pregnancy rate in the FVF programme during the same time period. We conclude that the older women in this study have a normal response to ovarian stimulation but may have a decreased receptivity of the endometrium or increased numbers of embryos with chromosomal abnormalities, leading to a reduced rate of implantation.

Key words: age/follicle stimulation/IVF


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