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Human Reproduction, Vol. 5, No. 3, pp. 266-270, 1990
© 1990 European Society of Human Reproduction and Embryology

research-article

Assisted fertilization in infertile women with patent Fallopian tubes. A comparison of in-vitro fertilization, gamete intra-Fallopian transfer and tubal embryo stage transfer

Tom Tanbo1, Per Olav Dale and Thomas A{ring}byholm

Department of Obstetrics and Gynaecology The National Hospital University of Oslo Oslo Norway

Correspondence: 1To whom correspondence should be addressed

A comparison of the relative efficacy of in-vitro fertilization with uterine embryo transfer (TVF), tubal embryo stage transfer (TEST) and gamete intra-Fallopian transfer (GIFT) was performed in infertile patients with patent Fallopian tubes. A total of 150 couples with unexplained infertility, peritoneal endometriosis or reduced semen quality were included in the study. The three groups were comparable with regard to age distribution, indications, semen parameters, stimulation regimens, response to stimulation and numbers of oocytes retrieved. In the IVF and TEST groups there was no cleavage in 24% and a cleavage rate of only 47.6%. The highest cleavage rate was obtained in the endometriosis patients. The pregnancy rate was highest in the two groups in which in-vitro fertilization was performed, IVF = 45.7%, TEST = 37.9%, GIFT = 26.2%. To obtain one live intrauterine fetus, more oocytes had to be transferred in the GIFT group comparedto the number of embryos in the IVF group, 14.4 versus 6.2, P < 0.05. Due to a high success rate of IVF but at the same time a high frequency of no cleavage in cases of unexplained infertility or male subfertility, we recommend FVF as the primary procedure in infertile couples with patent Fallopian tubes.

Key words: assisted fertilization/endometriosis/male subfetilitu/unexplained infertility


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