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Human Reproduction, Vol. 5, No. 3, pp. 274-278, 1990
© 1990 European Society of Human Reproduction and Embryology

research-article

An experimental model for salpingitis due to Chlamydia trachomatis and residual tubal infertility in the mouse

Jacques Zana4, Danielle Thomas1, Martine Muffat-Joly2, Jean de Brux3, Jean Jacques Pocidalo2, Jeanne Orfila1, Claude Carbon2 and Jacques Salat-Baroux

Service de Gynècologie Obstètrique, H⊚pital Tenon Paris 1Service de Bactèriologie et d'Immunologie gènèrale Amiens 2Institut National de la Santè et de la Recherche Mèdicale (INSERM) Unite 13 Hôpital Claude-Bernard Paris 3Institut de Pathologie et de Cytologie appliqu{varepsilon} Paris France

Correspondence: 4To whom correspondence should be addressed

A mouse model of salpingitis and subsequent tubal infertility induced by a human strain of Chlamydia trachomatis has been studied. C3H/He female mice were inoculated into the ovarian bursa. Some of the mice (six infected, five controls) were killed on days 15 and 23 and the remaining animals (10 infected, 10 controls) were mated on day 15. On day 15, the infection was maximal with intratubal inflammation, elevated anti-chlamydial antibody titre and positive cultures in 12 cases out of 16. After 19 weeks of housing with the male, the proportion of fertilized females was significantly lower in the infected group (20% versus 100% in the control group P < 0.01). In the killed mice, hydrosalpinx and or tubal occlusion were noted at this time in nine cases out of 10, despite an apparent bacteriological healing.

Key words: Chlamydia trachomatis salpingitis/mouse model/tubal infertility


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