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Human Reproduction, Vol. 5, No. 4, pp. 413-417, 1990
© 1990 European Society of Human Reproduction and Embryology

other

Follicular fluid renin concentration and IVF outcome

C.M. Cornwallis, S.L. Skinner1, P.L. Nayudu2, A. Lopata2, R.L. Thatche3, S.P. Yeung3 and J.A. Whitworth3

Departments of Physiology, University of Melbourne Parkville, Australia 3052 2Obstetrics and Gynaecology, University of Melbourne Parkville, Australia 3052 3Department of Nephrology, Royal Melbourne Hospital Melbourne, Australia

Correspondence: 1To whom correspondence should be addressed

Total renin protein concentration (TRC) was measured in stored follicular fluid (FF) samples from 42 women. Samples were selected according to their origin from follicles either without recovered ova (‘empty’, n = 38) or fertilized but with failed implantation (‘failed’, n = 36) or successful deliveries (‘deliveries’, n = 71). Ratios of number of embryos transfered to number of infants delivered were 2:1, 3:1 or 4:2 but 1:1 was not available. Non-parametric testing was applied to FF-TRC, volume and outcome. TRC was significantly higher in the delivery than the failed (P = 0.001) or empty (P = 0.002) categories. Assuming that the range of renin in failed follicles can identify the sub-population of unsuccessful follicles in the delivery category, then elevated FF-TRC was clearly associated with successful outcome. For individual women, the odds of infant delivery increased 17-fold as a function of average FF-TRC between 10 000 and 25 000 µIU/ml. For failed and delivery but not empty follicles, higher renin levels occurred in the smaller follicles, consistent with a burst of renin synthesis associated with the presence of an oocyte. The results suggest that FF-TRC relates to ovum viability with ovarian hyperstimulation and may have predictive use in IVF programmes.

Key words: ovarian renin-angiotensin system/renin gene expression/gonadotrophin/ovum viability/oocyte maturation/growth factors


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