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Human Reproduction, Vol. 5, No. 8, pp. 901-905, 1990
© 1990 European Society of Human Reproduction and Embryology

other

Medical treatment of mild endometriosis in infertile women: analysis of a failure

Giovanni Battista Candiani1, Paolo Vercellini1,3, Luigi Fedele1, Luca Bocciolone2 and Cosetta Bianchi2

1Centre for the Study and Treatment of Endometriosis, First Department of Obstetrics and Gynaecology, University of Milan School of Medicine Milan 2Istituto di Ricerche Farmacologiche ‘Mario Negri’ Milan, Italy

Correspondence: 3To whom correspondence should be addressed at Ia Clinica Ostetrica e Ginecologica ‘L. Mangiagalli’, Via Commenda 12, 20122 Milano, Italy

The easy access to the pelvis of infertile women by laparoscopy favours early diagnosis of endometriosis in an increasing number of subjects with minimal and mild disease. These initial forms have been associated with and considered as the cause of infertility despite the absence of relevant scientific evidence. Various hormone therapies, some with severe side-effects and high costs, have been used by numerous authors. However, no study comparing medically treated with untreated women has ever shown any drug to be more effective than expectant management. The possible explanations of treatment failures are reviewed.

Key words: endometriosis/infertility/danazol/gestrinone/gonadotrophin releasing hormone agonists


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