Skip Navigation

This Article
Right arrow Full Text (PDF )
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (23)
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Wikland, M.
Right arrow Articles by Sjöblom, P.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Wikland, M.
Right arrow Articles by Sjöblom, P.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Human Reproduction, Vol. 5, No. 8, pp. 920-923, 1990
© 1990 European Society of Human Reproduction and Embryology

other

The concentration of lidocaine in follicular fluid when used for paracervical block in a human IVF-ET programme

Matts Wikland1,, H. Evers2, A.-H. Jakobsson, U. Sandqvist and Peter Sjöblom

Fertilitetscentrum, Carlanders Hospital, Department of Obstetrics and Gynaecology, University of Göteborg Göteborg 2 Astra, Södertälje, Sweden

Correspondence: 1To whom correspondence should be addressed

Lidocaine is a well-documented local anaesthetic often used for paracervical block (PCB) in pregnant women. For this reason, the substance was used early on for PCB in connection with transvaginal follicle aspiration. However, the concentration reached in follicular fluid after PCB or local infiltration of the vaginal wall has not been previously determined. Furthermore, if lidocaine reaches the follicle, it seems important to determine if the concentration reached influences fertilization and early cleavage of the embryo and the pregnancy rate. The study included 46 women who had PCB with lidocaine (50 mg) and 46 women who had no PCB in connection with follicle aspiration. The mean concentration in follicular fluid was 0.36 ± 1.1 µg/ml. There was no significant difference in lidocaine concentration between follicles containing oocytes that were fertilized and those that were not. Furthermore, the fertilization and cleavage rates did not differ significantly in women with and without PCB with lidocaine. The pregnancy rate did not differ between the two groups. It thus seems that the concentration of lidocaine found in the follicular fluid after PCB with 50 mg lidocaine does not negatively affect fertilization of the human oocyte or early cleavage of the human embryo.

Key words: lidocaine/human embryo/IVF-ET


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Hum ReprodHome page
A. Cerne, C. Bergh, K. Borg, I. Ek, A.-L. Gejervall, T. Hillensjo, J. I. Olofsson, E. Stener-Victorin, M. Wood, and G. Westlander
Pre-ovarian block versus paracervical block for oocyte retrieval
Hum. Reprod., November 1, 2006; 21(11): 2916 - 2921.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
I. Kwan, S. Bhattacharya, F. Knox, and A. McNeil
Conscious sedation and analgesia for oocyte retrieval during IVF procedures: a Cochrane review.
Hum. Reprod., July 1, 2006; 21(7): 1672 - 1679.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
E. Stener-Victorin
The pain-relieving effect of electro-acupuncture and conventional medical analgesic methods during oocyte retrieval: a systematic review of randomized controlled trials
Hum. Reprod., February 1, 2005; 20(2): 339 - 349.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
E. Yasmin, M. Dresner, and A. Balen
Sedation and anaesthesia for transvaginal oocyte collection: an evaluation of practice in the UK
Hum. Reprod., December 1, 2004; 19(12): 2942 - 2945.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
P. Humaidan and E. Stener-Victorin
Pain relief during oocyte retrieval with a new short duration electro-acupuncture technique--an alternative to conventional analgesic methods
Hum. Reprod., June 1, 2004; 19(6): 1367 - 1372.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
I. Tummon, C. Newton, C. Lee, and J. Martin
Lidocaine vaginal gel versus lidocaine paracervical block for analgesia during oocyte retrieval
Hum. Reprod., May 1, 2004; 19(5): 1116 - 1120.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
E. Stener-Victorin, U. Waldenstrom, M. Wikland, L. Nilsson, L. Hagglund, and T. Lundeberg
Electro-acupuncture as a peroperative analgesic method and its effects on implantation rate and neuropeptide Y concentrations in follicular fluid
Hum. Reprod., July 1, 2003; 18(7): 1454 - 1460.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
E. H. Y. Ng, O. S. Tang, D. K. C. Chui, and P. C. Ho
Comparison of two different doses of lignocaine used in paracervical block during oocyte collection in an IVF programme
Hum. Reprod., October 1, 2000; 15(10): 2148 - 2151.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
I. Ben-Shlomo, R. Moskovich, J. Golan, V. Eyali, A. Tabak, and E. Shalev
The effect of propofol anaesthesia on oocyte fertilization and early embryo quality
Hum. Reprod., October 1, 2000; 15(10): 2197 - 2199.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
E. H. Y. Ng, O. S. Tang, D. K. C. Chui, and P. C. Ho
A prospective, randomized, double-blind and placebo-controlled study to assess the efficacy of paracervical block in the pain relief during egg collection in IVF
Hum. Reprod., November 1, 1999; 14(11): 2783 - 2787.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
I. Ben-Shlomo, R. Moskovich, Y. Katz, and E. Shalev
Midazolam/ketamine sedative combination compared with fentanyl/propofol/isoflurane anaesthesia for oocyte retrieval
Hum. Reprod., July 1, 1999; 14(7): 1757 - 1759.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.