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Human Reproduction, Vol. 5, No. 8, pp. 924-927, 1990
© 1990 European Society of Human Reproduction and Embryology

other

Effects of antiprogestogen (RU-486) treatment on myometrial and cervical alpha and beta-adrenoceptors in pregnant rabbits

G. Falkay

Department of Obstetrics and Gynaecology, WHO Collaborative Centre on Clinical Research on Human Reproduction, Albert Szent-Györgyi Medical University Szeged Semmelweis u.l., Hungary

Oestrogen and progesterone influence myometrial and cervical responses at different levels of the mechanisms regulating uterine contractility. One of these mechanisms could involve alterations in the adrenoceptor concentrations. This study was undertaken to assess the effects of treatment with the antiprogestogen RU-486 on the concentrations of {alpha}-and {beta}-adrenoceptors in pregnant rabbit myometrial and cervical membranes by means of a radioligand binding technique. The probable relative oestrogen dominance due to the antiprogestogen treatment selectively decreased the {alpha}2-adrenoceptor subtype in the cervix, where an {alpha}-adrenoceptor dominance was found on day 27 of pregnancy. The results indicate a heterologous regulation of {alpha}-adrenoceptors by sex steroids, i.e. suppression of the {alpha}2-adrenoceptor concentration by antiprogestogen treatment.

Key words: adrenoceptors/antiprogestogen/cervix/myometrium


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