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Human Reproduction, Vol. 5, No. 8, pp. 933-937, 1990
© 1990 European Society of Human Reproduction and Embryology

other

Incidence of severe ovarian hyperstimulation syndrome after GnRH agonist/HMG superovulation for in-vitro fertilization

J. Smitz1, M. Camus, P. Devroey, P. Erard, A. Wisanto and A.C. Van Steirteghem

Centre for Reproductive Medicine, Academic Hospital, Vrije Universiteit Brussel Laarbeeklaan 101, B 1090 Brussels, Belgium

Correspondence: 1To whom correspondence should be addressed

In 1673 treatment cycles stimulated with buserelin and HMG, for IVF, GIFT or ZIFT, the severe ovarian hyperstimulation syndrome (OHSS) occurred in 10 cycles (0.6%). Eight patients were hyperandrogenic and showed an increased ovarian response to HMG. After replacement of a maximum of three embryos or zygotes, seven women became pregnant. Three women had a multiple gestation. All patients recovered uneventfully with conservative treatment. Support with progesterone or continuation of the agonist during the luteal phase did not prevent OHSS, confirming that the ovulatory HCG dose is the most important factor in inducing this severe complication. Luteal supplementation with HCG and/or HCG production during implantation could exacerbate OHSS.

Key words: GnRH agonist/in-vitro fertilization/ovarian stimulation/polycystic ovary disease


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