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Human Reproduction, Vol. 5, No. 8, pp. 965-970, 1990
© 1990 European Society of Human Reproduction and Embryology

other

The impact of treatment on the natural history of endometriosis

Tahir A. Mahmood1 and Allan Templeton

Department of Obstetrics and Gynaecology, Aberdeen Maternity Hospital Cornhill Road, Aberdeen AB9 2ZD, UK

Correspondence: 1To whom correspondence should be addressed

A group of 50 infertile female patients was assessed laparo-scopically to study the natural history of endometriosis. They were treated either with danazol (n = 21), or diathermy ablation (n = 13) or had conservative surgery with postoperative danazol (n = 5) or were left untreated (n = 11). All these patients had second look laparoscopy performed after a mean interval of 12 months (range 9–18 months). Improvement was noted among 53% of those treated with danazol, 70% treated with diathermy, 80% treated with surgery and danazol and 27% of those left untreated. The status of endometriosis remained unchanged among 14% of those treated with danazol, 8% treated by diathermy and 9% of those left untreated. However, the disease became worse in the remaining women, 33% in the danazol treated group, 22% treated by diathermy, 20% treated with surgery and danazol and 64% of those left untreated. Thus treatment hinders progression in a majority of patients, and conversely, there is a small but definite spontaneous regression rate.

Key words: endometriosis/natural history/treatment


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