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Human Reproduction, Vol. 6, No. 7, pp. 910-913, 1991
© 1991 European Society of Human Reproduction and Embryology

other

Interleukin-1{alpha} modulates luteinizing hormone stimulated cyclic AMP and progesterone release from human granulosa cells in vitro

Anita Sjögren, Paul V. Holmes1 and Torbjörn Hillensjö

Department of Obstetrics and Gynaecology, University of Göteborg, Sahlgrenska Hospital S-413 45 Göteborg, Sweden

Correspondence: 1To whom correspondence should be addressed

This study examines the possible direct effect of interleukin-1{alpha} (IL-1{alpha}) upon human granulosa cells. The cells were isolated from follicles of stimulated cycles in women undergoing oocyte retrieval for in-vitro fertilization. Purified cell preparations were cultured for different time periods in the presence of IL-1{alpha} and human luteinizing hormone (LH) or follicle stimulating hormone. IL-1{alpha} stimulated basal as well as LH-induced progesterone accumulation. The response in terms of cyclic AMP was more complex, there was no effect of IL-1{alpha} on basal cyclic AMP accumulation. However, at the highest concentration tested (50 IU/ml), IL-1{alpha} enhanced cyclic AMP accumulation over that seen with LH alone. At a lower concentration, IL-1{alpha} either had no effect or was slightly inhibitory to the LH-induced cyclic AMP accumulation, depending on the culture period. Our results, taken together with other findings, are compatible with the view that IL-1{alpha} has a potential regulatory role in the granulosa-luteal cell transition in the human ovary.

Key words: interleukin-1{alpha}/human granulosa/cyclic AMP/progesterone/LH-FSH


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A. Hurwitz, Z. Finci-Yeheskel, M. Dushnik, A. Milwidsky, S. Shimonovitz, S. Yagel, E. Y. Adashi, and M. Mayer
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