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Human Reproduction, Vol. 6, No. 7, pp. 931-933, 1991
© 1991 European Society of Human Reproduction and Embryology

other

Short communication

Use of the hormonal response to clomiphene citrate as an endocrinological indicator of ovarian ageing

S. Nader1 and A.S. Berkowitz

Department of Obstetrics, Gynecology and Reproductive Sciences, University of Texas Medical School Houston, 6431 Fannin, #3.204 Houston, TX 77030, USA

Correspondence: 1To whom correspondence should be addressed

We compared the gonadotrophin and oestradiol responses to clomiphene citrate (CC) in women aged 18–25 versus 35–40 years. Despite similar baseline hormone concentrations and the attainment of similar concentrations of the E and Z isomers of clomiphene, higher follicle stimulating hormone (FSH) concentrations were observed in the older women, possibly indicative of their ageing ovaries. Furthermore, diminished oestradiol responses occurred in a subgroup of women showing FSH hyper-responsiveness to CC. These preliminary results support the concept that the hormonal response to CC may be an indicator of approaching perimenopause.

Key words: ageing/clomiphene citrate/gonadotrophins/ovary


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