Human Reproduction, Vol. 6, No. 7, pp. 947-952, 1991
© 1991 European Society of Human Reproduction and Embryology
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Multiple follicular recruitment and intrauterine insemination outcomes compared by age and diagnosis*
Division of Reproductive Sciences, University of Toronto, The Toronto Hospital 200 Elizabeth Street, Toronto, Ontario, Canada M5G 2C4
Correspondence: 1To whom correspondence should be addressed
We studied the outcome of our intrauterine insemination (IUI) programme, evaluating female age and diagnosis. One-hundred-and-twenty-six patients <36 years of age (mean 30.91 ± 3.02 years) completed 306 cycles of multiple follicular recruitment (MFR) and timed IUI; 64 patients 
36 years of age (mean 38.36 ± 2.08 years) completed 166 cycles (total 190 patients, 472 cycles). The male partners' semen was prepared for IUI with wash and swim-up techniques. Diagnostic groups were: male factor (n = 26), idiopathic (n = 33), endometriosis (n = 19), ovulatory disorder (n = 7), other (n = 19) and combined factors (n = 86). Pregnancy rates (% per couple, % per cycle) [overall (31.58, 12.7)] [<36 years (38.10, 15.69)] [>36 years (18.75, 7.23)] were greater in the <36 years group (P < 0.025). The probability of conception after three treatment cycles was 0.402 overall, 0.481 for age <36 years and 0.252 for age 36 years. The probability of conception for male factor and idiopathic infertility patients was 0.469 and 0.411 respectively. An age effect was found on pregnancy rates in the idiopathic group only. In conclusion, MFR + IUI is a valuable treatment especially for male factor patients and patients <36 years old, with idiopathic infertility.
Key words: intrauterine insemination/age/idiopathic infertility/male factor
*Preliminary data from this study were presented at the annual meeting of the American Fertility Society, October, 1990, Washington, DC.