Human Reproduction, Vol. 6, No. 7, pp. 969-978, 1991
© 1991 European Society of Human Reproduction and Embryology
review-article |
REVIEW
Some disturbances of acrosomal development and function in human spermatozoa*
Department of Dermatology and Andrology, Justus Liebig University Gaffkystrasse 14, W-6300 Giessen, FRG
Disturbances of acrosomal development and function significantly impair the fertilizing capacity of spermatozoa. Therefore, evaluation of acrosomal morphology and function is of particular importance in the diagnostic testing of male infertility. Acrosomal disturbances include either specific defects showing a complete absence of certain acrosomal structures or various acrosomal malformations in combination with nuclear or flagellar defects which indicate acquired testicular disorders. As examples of specific acrosomal defects, the syndrome of round-headed spermatozoa (globozoospermia), the crater defect syndrome and the syndrome of decapitated spermatozoa are discussed. In addition to disturbances of acrosomal morphology, the assessment of acrosomal proteinase activity and the acrosome reaction as a method of evaluating impaired acrosomal functions is discussed. Clinical examples demonstrate the importance of these sperm function tests in the fertility testing of infertile men.
Key words: acrosomal development/acrosomal defects/acrosomal function/acrosin/acrosome reaction
*Presented at the 2nd Düsseldorf Symposium on Interactions in Reproductive Medicine, November 18–20, 1990. Prepared for publication by N.J.Alexander, G.Freundl and V.Insler.
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