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Human Reproduction, Vol. 7, No. 5, pp. 606-607, 1992
© 1992 European Society of Human Reproduction and Embryology

other

CASE REPORT: Simultaneous induction of multiple follicular development with gonadotrophins and steroid replacement for in-vitro fertilization

Antonio Pellicer1, María J. De los Santos and José Remohí

Instituto Valenciano de Infertilidad, and Department of Paediatrics, Obstetrics and Gynaecology, Valencia University School of Medicine Valencia 46020, Spain

Correspondence: 1To whom correspondence should be addressed

Simultaneous administration of follicle stimulating hormone, oestradiol valerate and progesterone was employed in a patient with a possible enzymatic deficiency involving low production of oestradiol. The patient became pregnant after in-vitro fertilization. This case demonstrates that this treatment is useful in women with low oestradiol production and subsequent inadequate endometrial development; it also illustrates the role of oestradiol in follicular development and questions the importance of serum oestradiol measurements in the monitoring of ovulation induction.

Key words: enzyme deficiency/IVF/low oestradiol/ovarian stimulation/steroid replacement


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