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Human Reproduction, Vol. 7, No. 5, pp. 652-653, 1992
© 1992 European Society of Human Reproduction and Embryology

other

Replacement of frozen embryos generated from epididymal spermatozoa: the first two pregnancies

P. Patrizio1,3, S. Silber2, T. Ord1, E. Marello1, J.P. Balmaceda1 and R.H. Asch1

1University of California Irvine, Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology Orange, CA, USA 2Department of Urology and Microsurgery, St Luke's Hospital St Louis, USA

Correspondence: 3To whom correspondence should be addressed at: University of California Irvine, Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology, UCI Medical Center, UCI Medical Center for Reproductive Health, 101 The City Drive South, Pavilion 2, Orange, CA 92668, USA

This report describes the first two pregnancies which occurred after cryopreservation, thawing and transfer of embryos generated using epididymal spermatozoa from men with congenital absence of the vas deferens. Of the 32 embryos that were thawed, 24 survived (75%) and were replaced in seven transfer cycles resulting in two (29%) pregnancies successfully delivered. The demonstration that excess embryos obtained with the use of epididymal spermatozoa can be safely frozen/thawed, and that their survival is not different from other embryos generated by in-vitro fertilization, represents a great advantage for the reproductive performance of men with congenital absence of the vas deferens undergoing microsurgical aspiration of epididymal spermatozoa.

Key words: absence of vas deferens/epididymal spermatozoa/frozen embryos/obstructive azoospermia


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