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Human Reproduction, Vol. 7, No. 7, pp. 994-998, 1992
© 1992 European Society of Human Reproduction and Embryology

other

Pronuclear, cleavage and blastocyst histories in the attempted preimplantation diagnosis of the human hydatidiform mole

R.G. Edwards1,2, J. Crow, S. Dale, M.C. Macnamee, G.M. Hartshorne3 and P. Brinsden

Bourn Hall Bourn, Cambridge, CB3 7TR, UK 2Churchill College Storeys Way, Cambridge, UK 3Darwin College Silver Street, Cambridge, CB3 9EU, UK

Correspondence: 1To whom correspondence should be addressed at: Bourn Hall, Bourn, Cambridge CB3 7TR, UK

We report a study of fertilization, syngamy and embryonic development in 14 oocytes from a woman with four previous pregnancies involving complete hydatidiform moles. Serial observations of pronuclear movements and syngamy were compared to those in a group of 10 multipronucleate embryos from other patients. One embryo and possibly two others developed normally or near-normally. The others displayed immediate cleavage or had one or three pronuclei. The tripronucleate eggs displayed various anomalous forms of growth. The unipronucleate eggs passed through a double form of syngamy, which might have involved chromosome doubling, and could have developed as androgenetic diploids. We suggest a hypothesis to explain these unusual observations.

Key words: preimplantation diagnosis/hydatidiform mole/syn-gamy/pronuclei/androgenesis


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