Human Reproduction, Vol. 7, No. 8, pp. 1061-1966, 1992
© 1992 European Society of Human Reproduction and Embryology
other |
Endothelial cell migratory signal produced by human endometrium during the menstrual cycle
Department of Obstetrics and Gynaecology, Monash University 246 Clayton Road, Clayton, Victoria 3168, Australia 2Department of Anatornical Pathology, Monash Medical Centre 246 Clayton Road, Clayton, Victoria 3168, Australia
Correspondence: 1To whom correspondence should be addressed
Human endometrial explants were cultured in a three-dimensional collagen/bovine aortic endothelial cell (BAEC) matrix to measure angiogenic activity, as represented by migration of BAEC towards the explants. The 57 endometrial biopsies were classified by histological appearance into nine stages of the menstrual cycle; five proliferative groupings, three secretory groupings and one menstrual. The BAEC migratory score was taken as the average for 12 explants assayed from each biopsy. The results showed two significant peaks of BAEC migratory activity, one during the early proliferative phase and one during the mid–late proliferative phase. There was a significant drop in the BAEC migratory signal from early–mid-proliferative endometrial explants compared to most other stages of the cycle. The results also show a non-significant rise in BAEC migratory activity in the mid-secretory phase of the cycle. Overall, the results support the concept of two or three different endometrial angiogenic events during the human menstrual cycle, a post-menstrual repair, a mid–late proliferative growth and a lesser mid-secretory activity that may be associated with spiral arteriole growth. Each of these events occurs under different hormonal environments and will need to be investigated separately in terms of local mechanisms controlling angiogenesis.
Key words: angiogenesis/endometrium/endothelial cell/human/menstrual cycle
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  Y.-L. Lee, Y. Liu, P.-Y. Ng, K.-F. Lee, C.-L. Au, E. H.-Y. Ng, P.-C. Ho, and W. S.-B. Yeung Aberrant expression of angiopoietins-1 and -2 and vascular endothelial growth factor-A in peri-implantation endometrium after gonadotrophin stimulation Hum. Reprod., April 1, 2008; 23(4): 894 - 903. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Sengupta, L. Dhawan, P G L Lalitkumar, and D Ghosh Nitric oxide in blastocyst implantation in the rhesus monkey Reproduction, September 1, 2005; 130(3): 321 - 332. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. R. Nayak and R. M. Brenner Vascular Proliferation and Vascular Endothelial Growth Factor Expression in the Rhesus Macaque Endometrium J. Clin. Endocrinol. Metab., April 1, 2002; 87(4): 1845 - 1855. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. W. M. Maas, P. G. Groothuis, G. A. J. Dunselman, A. F.P.M. de Goeij, H. A.J.S. Boudier, and J. L. H. Evers Endometrial angiogenesis throughout the human menstrual cycle Hum. Reprod., August 1, 2001; 16(8): 1557 - 1561. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Koolwijk, K. Kapiteijn, B. Molenaar, E. van Spronsen, B. van der Vecht, F. M. Helmerhorst, and V. W. M. van Hinsbergh Enhanced Angiogenic Capacity and Urokinase-Type Plasminogen Activator Expression by Endothelial Cells Isolated from Human Endometrium J. Clin. Endocrinol. Metab., July 1, 2001; 86(7): 3359 - 3367. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. R. Kini, L. C. Peterson, M. S. Tallman, and M. W. Lingen Angiogenesis in acute promyelocytic leukemia: induction by vascular endothelial growth factor and inhibition by all-trans retinoic acid Blood, June 15, 2001; 97(12): 3919 - 3924. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Schachter, A. Raziel, S. Friedler, D. Strassburger, O. Bern, and R. Ron-El Monozygotic twinning after assisted reproductive techniques: a phenomenon independent of micromanipulation Hum. Reprod., June 1, 2001; 16(6): 1264 - 1269. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Sandberg, A. Ehinger, and B. Casslén Paracrine Stimulation of Capillary Endothelial Cell Migration by Endometrial Tissue Involves Epidermal Growth Factor and Is Mediated Via Up-Regulation of the Urokinase Plasminogen Activator Receptor J. Clin. Endocrinol. Metab., April 1, 2001; 86(4): 1724 - 1730. [Abstract] [Full Text]
|
|
|
|
|
|
X. F. Li, D. S. Charnock-Jones, E. Zhang, S. Hiby, S. Malik, K. Day, D. Licence, J. M. Bowen, L. Gardner, A. King, et al. Angiogenic Growth Factor Messenger Ribonucleic Acids in Uterine Natural Killer Cells J. Clin. Endocrinol. Metab., April 1, 2001; 86(4): 1823 - 1834. [Abstract] [Full Text]
|
|
|
|
 |
|
 M. D. Graubert, M. Asuncion Ortega, B. Kessel, J. F. Mortola, and M. L. Iruela-Arispe Vascular Repair After Menstruation Involves Regulation of Vascular Endothelial Growth Factor-Receptor Phosphorylation by sFLT-1 Am. J. Pathol., April 1, 2001; 158(4): 1399 - 1410. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. E. King, H. O.D. Critchley, and R. W. Kelly The NF-{{kappa}}B pathway in human endometrium and first trimester decidua Mol. Hum. Reprod., February 1, 2001; 7(2): 175 - 183. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Moller, C. Rasmussen, B. Lindblom, and M. Olovsson Expression of the angiogenic growth factors VEGF, FGF-2, EGF and their receptors in normal human endometrium during the menstrual cycle Mol. Hum. Reprod., January 1, 2001; 7(1): 65 - 72. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Ghosh, A.M. Sharkey, D.S. Charnock-Jones, L. Dhawan, S. Dhara, S.K. Smith, and J. Sengupta Expression of vascular endothelial growth factor (VEGF) and placental growth factor (PlGF) in conceptus and endometrium during implantation in the rhesus monkey Mol. Hum. Reprod., October 1, 2000; 6(10): 935 - 941. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. M. Sharkey, K. Day, A. McPherson, S. Malik, D. Licence, S. K. Smith, and D. S. Charnock-Jones Vascular Endothelial Growth Factor Expression in Human Endometrium Is Regulated by Hypoxia J. Clin. Endocrinol. Metab., January 1, 2000; 85(1): 402 - 409. [Abstract] [Full Text]
|
|
|
|
|
|
A. Abu-Musa, A. Hannoun, A. Khabbaz, and P. Devroey Failure of fertilization after intracytoplasmic sperm injection in a patient with Kartagener's syndrome and totally immotile spermatozoa: Case Report Hum. Reprod., October 1, 1999; 14(10): 2517 - 2518. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M.W. Lingen Angiogenesis in the Development of Head and Neck Cancer and Its Inhibition By Chemopreventive Agents Critical Reviews in Oral Biology & Medicine, January 1, 1999; 10(2): 153 - 164. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Sandberg,, B. Casslén,, B. Gustavsson,, and T. J. Benraad Human Endothelial Cell Migration Is Stimulated by Urokinase Plasminogen Activator:Plasminogen Activator Inhibitor 1 Complex Released from Endometrial Stromal Cells Stimulated with Transforming Growth Factor ß1; Possible Mechanism for Paracrine Stimulation of Endometrial Angiogenesis Biol Reprod, October 1, 1998; 59(4): 759 - 767. [Abstract] [Full Text]
|
|