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Human Reproduction, Vol. 7, No. 8, pp. 1079-1984, 1992
© 1992 European Society of Human Reproduction and Embryology

other

Effects of short-term GnRH agonist - human menopausal gonadotrophin stimulation in patients pre-treated with progestogen

J. N. Hugues1, M. Attalah, F. Hervé, B. Martin-Pont, M. L. Kottler2 and J. Santarelli

Unité de Procréation Médicalement Assistée, Hôpital Jean Verdier Avenue du 14 Juillet. Bondy 93143 2Laboratoire de Biochimie Médicale. Université Paris V Paris 75006, France

Correspondence: 1To whom correspondence should be addressed

The recent use of gonadotrophin-releasing hormone agonist in a short-term regimen has allowed the effectiveness of human menopausal gonadotrophin (HMG) stimulation to be markedly improved. It seems to be related to the flare-up effect of the agonist in the early follicular phase of the cycle. However, individual hormonal responses to the agonist are quite variable and four patterns of oestradiol secretion have been described. The present study indicates that in women pre-treated with progestogen, only two patterns of serum oestradiol are observed in the flare-up period, with a significant increase in 57% of patients. Significant correlations are observed between oestradiol values and the endogenous gonadotrophin surge (positively with luteinizing hormone, r = 0.38; P < 0.05 and negatively with follicle stimulating hormone, r = 0.48; P < 0.005). Furthermore, there was a significant relationship between the hormonal flare-up and the ovarian parameters following HMG stimulation. In conclusion, in progestogen-pre-treated women, the serum oestradiol level during the flare-up period is a reliable index to predict subsequent effectiveness of ovarian stimulation with HMG.

Key words: IVF - ET/ovarian stimulation/progestogen pretreatment/short protocol


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I. Cedrin-Durnerin, J.-M. Bidart, P. Robert, J.-P. Wolf, M. Uzan, and J.-N. Hugues
Consequences on gonadotrophin secretion of an early discontinuation of gonadotrophin-releasing hormone agonist administration in short-term protocol for in-vitro fertilization
Hum. Reprod., May 1, 2000; 15(5): 1009 - 1014.
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