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Human Reproduction, Vol. 7, No. suppl_1, pp. 107-110, 1992
© 1992 European Society of Human Reproduction and Embryology

Preimplantation diagnosis

I. Liebaers1,4, K. Sermon1, W. Lissens1, J. Liu2, P. Devroey2, B. Tarlatzis3 and A. Van Steirteghem2

1 Centre for Medical Genetics, University Hospital, Dutch-speaking Brussels Free University (Vrije Universiteit Brussel, VUB) Laarbeeklaan 101, B-1090 Brussels, Belgium 2 Centre for Reproductive Medicine, University Hospital, Dutch-speaking Brussels Free University (Vrije Universiteit Brussel, VUB) Laarbeeklaan 101, B-1090 Brussels, Belgium 3 First Department of Obstetrics and Gynaecology, Aristotelean University of Thessaloniki Greece

Correspondence: 4To whom correspondence should be addressed

Although healthy babies have been born after preimplantation diagnosis for sex determination, this technique is still in an experimental phase. To date, removal by micromanipulation of one or two blastomeres from an eight-cell embryo seems an acceptable procedure. Since a reasonable number of biopsied embryos will implant and develop in utero, the methodology for the analysis of the blastomeres at the chromosomal, gene product or DNA level, needs to be improved before further clinical application. In the meanwhile, more information about early embryo development will become available.

Key words: Preimplantation diagnosis/micromanipulation/enzyme assay/DNA-amplification


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