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Human Reproduction, Vol. 7, No. suppl_1, pp. 31-38, 1992
© 1992 European Society of Human Reproduction and Embryology

Endometrial proteins: A reappraisal

Markku Seppälä, Mervi Julkunen, Leena Riittinen and Riitta Koistinen

Department 1 of Obstetrics and Gynaecology, Helsinki University Central Hospital SF-00290 Helsinki, Finland

Uterine factors influence reproduction at the macro-anatomy level, and the effects of hormonal steroids on endometrial morphology are well recognized in the histopathological diagnosis of dysfunctional bleeding and infertility. During the past decade, attention has been paid to endometrial protein synthesis and secretion with respect to endocrine stimuli and implantation, and to the paracrine/autocrine effects of endometrial peptide growth factors, their binding proteins and other factors. The emphasis of this presentation is on protein secretion of the secretory endometrium, in which progesterone plays a pivotal role. Insulin-like growth factors have receptors on the endometrium, and IGF-binding proteins, stimulated by progesterone, modulate the effects of IGFs locally. Also other protein products of the secretory endometrium have been reviewed in this communication, with special emphasis on studies of a progesterone-associated endometrial protein which has many names in the literature, such as PEP, PP14, {alpha}2-PEG and AUP. Extensive studies are ongoing in many laboratories to elucidate the regulation, function, interplay at tissue and cellular levels, and clinical significance of these proteins.

Key words: endometrion/protein/PP14/IGF


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