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Human Reproduction, Vol. 8, No. 1, pp. 60-64, 1993
© 1993 European Society of Human Reproduction and Embryology

other

Effects of age, gravidity and male infertility status on cumulative conception rates following artificial insemination with cryopreserved donor semen: analysis of 2998 cycles of treatment in one centre over 10 years

F. Shenfield1, P. Doyle2, A. Valentine1, S.J. Steele1 and S.-L. Tan3,4

1Fertility Unit, The Middlesex Hospital London, UK 2Department of Epidemiology and Population Sciences, London School of Hygiene and Tropical Medicine London, UK 3Department of Obstetrics and Gynaecology, King's College School of Medicine and Dentistry London, UK

Correspondence: 4To whom correspondence should be addressed

The effects of age, gravidity and male infertility status on cumulative conception rates after donor insemination were investigated in an analysis of 2998 treatment cycles undertaken on 443 patients. It was found that the cumulative conception rates affer 3, 6 and 12 cycles of treatment were 21, 40 and 62% respectively for patients < 30 years of age compared with 17, 26 and 44% for those aged ≥ 30 years (P = 0.008). There was also a significant difference (P < 0.001) in results depending on course of treatment and the cumulative conception rates were 19% after 3 cycles, 33% after 6 cycles and 54% after 12 cycles of treatment in the first course of treatment compared with 40, 67 and 79% respectively in those who returned for subsequent courses of treatment after having achieved a donor insemination pregnancy in the first treatment course. Gravidity and male infertility status (azoospermia or oligozoospermia/asthenozoospermia) did not significantly affect the cumulative conception rates.

Key words: age/cumulative conception rate/donor insemination/parity


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