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Human Reproduction, Vol. 8, No. 10, pp. 1576-1578, 1993
© 1993 European Society of Human Reproduction and Embryology

research-article

Physiology: The regulatory role of tri-iodothyronine on the production of {alpha}-fetoprotein and albumin by mouse fetal liver cells*

Eyal Anteby1, Perach Shpan1, Matat Dushnik1, Adi Zvang1, Tamar Zer2, Ziva Ben-Neriah3 and Simcha Yagel1,4

1Department of Obstetrics and Gynaecology and Molecular Biology Unit Hadassah Mt. Scopus, Jerusalem 2Zer Laboratory Jerusalem 3Department of Genetics, Hadassah Ein Karem Jerusalem, Israel

Correspondence: 4To whom correspondence should be addressed at: Department of Obstetrics and Gynaecology, Hadassah Mt. Scopus, Jerusalem, POB 24035, Israel

The purpose of this study was to assess possible effects of tri-iodothyronine (T3) on the production of alpha fetoprotein (AFP) and albumin by mouse fetal liver cells. AFP from serum-free conditioned media of TIB73 mouse fetal liver cells was measured by immunoradiometric assay and albumin was measured by chromogenic assay. The expression of mRNAs was quantified by Northern blotting analysis. A marked inhibition of AFP secretion was found as well as an increase in albumin produced by T3 in a dose-dependent manner. The effects of T3 AFP and albumin secretion paralleled the effects of T3 on the steady-state expression of mRNAs encoding albumin and AFP. These data may point to a possible role of T3 in the transcriptional switch from AFP to albumin during fetal development and may explain the observation of high levels of AFP in cases of congenital hypothyroidism.

Key words: albumin/{alpha}-fetoprotein/hepatocytes/mouse/tri-iodothyronine

*Presented at the 39th Annual Meeting of the Society for Gynaecological Investigation, San Antonio, TX, USA, 1992.


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