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Human Reproduction, Vol. 8, No. 10, pp. 1640-1644, 1993
© 1993 European Society of Human Reproduction and Embryology

research-article

Endocrinology: The possible involvement of tissue type plasminogen activator in luteolysis of rhesus monkey

Feng Qiang1,3, Liu Kui1, Hu Zhao-yuan1, Zou Ru-jin2, Yang Shang chuan2 and Liu Yi-xun1,4

1State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences Beijing, PRC 100080 2Primate Research Centre, Kunming Institute of Zoology, Chinese Academy of Sciences People's Republic of China 650107

Correspondence: 4To whom correspondence should be addressed

Changes of plasminogen activators (PA) during different stages of development of the corpus luteum, and their possible physiological role in luteolysis were studied in rhesus monkeys. It was demonstrated for the first time that monkey corpus luteal cells not only produce PA, but that the function of the corpus luteum is also closely related to the activity of this enzyme system. Generally, the life span for a corpus luteum in monkey is approximately 14–16 days, its demise beginning thereafter. In the present study, we found that urokinase in the corpus luteum is higher on day 5 and day 10 after human chorionic gonadotrophin injection, while the tissue type (t) PA is mainly produced on day 13 when luteolysis may take place. Progesterone production remained high on day 5 and day 10 and decreased dramatically from day 13, indicating the important role of tPA but not urokinase (u) PA in suppressing luteal function. When purified tPA (but not uPA) monoclonal antibody was added to luteal cell culture to neutralize endogenously produced tPA activity, progesterone production in the cells was increased significantly. Interestingly, prolactin alone was capable of increasing PA production by luteal cells; prolactin together with luteinizing hormone, however, had a synergistic luteotrophic effect.

Key words: luteolysis/rhesus monkey/tissue type plasminogen activator

3Present address: European Community Postdoctoral Fellow, Department of Molecular Cell Biology, University of Copenhagen, Øster Farimagsgade 2A, DK-1353 Copenhagen K, Denmark


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