Skip Navigation

This Article
Right arrow Full Text (PDF )
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (25)
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Mordel, N.
Right arrow Articles by Schenker, J. G.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Mordel, N.
Right arrow Articles by Schenker, J. G.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Human Reproduction, Vol. 8, No. 12, pp. 2009-2014, 1993
© 1993 European Society of Human Reproduction and Embryology

review-article

Gonadotrophin-releasing hormone agonist and ovarian hyperstimulation syndrome in assisted reproduction

Nathan Mordel and Joseph G. Schenker1

Department of Obstetrics and Gynaecology, Hebrew University Hadassah Medical Centre Kiryat Hadassah, P.O.B. 12000, Jerusalem, Israel

Correspondence: 1To whom correspondence should be addressed

The available literature concerning the association between gonadotrophin-releasing hormone agonist and ovarian hyperstimulation syndrome has been reviewed and the different patterns by which this agent may contribute to the development of such iatrogenic complication has been elicited, and guidelines have been presented for prevention of this malady. Gonadotrophin-releasing hormone agonist acts directly on human granulosa cells, probably in its own dose-dependent manner. The extent of this action is probably subjected to follicular maturation stage and to the degree of gonadotrophin pre-treatment. Various agonist effects in assisted reproduction may be implicated in the development of ovarian hyperstimulation syndrome: a higher amount of menotrophin; premature luteinization prevention; ‘flare-up’ effect; and a higher pregnancy rate. Different methods for prevention of ovarian hyperstimulation syndrome may be attempted: (i) all embryo cryopreservation with luteal phase reinitiation of agonist; (ii) avoidance of ovulatory human chorionic gonadotrophin (HCG) and continuation of agonist; (iii) cancellation of ovulatory HCG, prolongation of agonist and later recommencement of menotrophin; (iv) pre-ovulatory LH surge triggering by agonist instead of the conventional HCG. Gonadotrophin-releasing hormone agonist may affect the steroidogenic ovarian stroma directly and such interaction may aggravate the development of ovarian hyperstimulation syndrome.

Key words: gonadotrophin releasing hormone agonist/human granulosa cells/ovarian hyperstimulation syndrome/ovulation induction


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Hum ReprodHome page
M. Huser, I. Crha, P. Ventruba, R. Hudecek, J. Zakova, L. Smardova, Z. Kral, and J. Jarkovsky
Prevention of ovarian function damage by a GnRH analogue during chemotherapy in Hodgkin lymphoma patients
Hum. Reprod., April 1, 2008; 23(4): 863 - 868.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
G. Ragni, W. Vegetti, A. Riccaboni, B. Engl, C. Brigante, and P.G. Crosignani
Comparison of GnRH agonists and antagonists in assisted reproduction cycles of patients at high risk of ovarian hyperstimulation syndrome
Hum. Reprod., September 1, 2005; 20(9): 2421 - 2425.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
T. Katayama, Y. Kusanagi, M. Kiyomura, H. Ochi, and M. Ito
Leukocyte behaviour and permeability in the rat mesenteric microcirculation following induction of ovulation
Hum. Reprod., June 1, 2003; 18(6): 1179 - 1184.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
M.I. Abuzeid, Z. Nassar, Z. Massaad, M. Weiss, M. Ashraf, and M. Fakih
Pigtail catheter for the treatment of ascites associated with ovarian hyperstimulation syndrome
Hum. Reprod., February 1, 2003; 18(2): 370 - 373.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
A.P. Ferraretti, L. Gianaroli, C. Magli, D. Fortini, H.A. Selman, and E. Feliciani
Elective cryopreservation of all pronucleate embryos in women at risk of ovarian hyperstimulation syndrome: efficiency and safety
Hum. Reprod., June 1, 1999; 14(6): 1457 - 1460.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.