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Human Reproduction, Vol. 8, No. 12, pp. 2033-2038, 1993
© 1993 European Society of Human Reproduction and Embryology

review-article

Endocrinology: The induction of ovulation with pulsatile gonadotrophin-releasing hormone (GnRH) administration in hyperandrogenic women after down-regulation with buserelin or suppression with an oral contraceptive

I. Gerhard1, J. Matthes and B. Runnebaum

Department of Gynaecological Endocrinology, Women's Hospital, University of Heidelberg Voss-Strasse 9, 69115 Heidelberg, Germany

Correspondence: 1To whom correspondence should be addressed

The hypothalamic—pituitary axis of 22 hyperandrogenic infertile women had suppression with either the gonadotrophin-releasing hormone (GnRH)-analogue buserelin (n = 12) or with an oestrogen—gestagen compound (Diane®; n = 12). This was followed by pulsatile GnRH application for inducing ovulation (Zyklomat®). In terms of ovulation and pregnancy rates the buserelin pre-treatment was more effective than the steroid pre-treatment, especially in hyperandrogenic non-polycystic ovaries (PCO).

Key words: buserelin/hyperandrogenism/PCO/pulsatile GnRH


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