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Human Reproduction, Vol. 8, No. 5, pp. 660-666, 1993
© 1993 European Society of Human Reproduction and Embryology

review-article

Methotrexate therapy of tubal pregnancy

M. Goldenberg1, D. Bider, D. Admon, S. Mashiach and G. Oelsner

Department of Obstetrics and Gynaecology, The Chaim Sheba Medical Center, and Sackler School of Medicine, Tel Aviv University Tel Hashomer, 52621, Israel

Correspondence: 1To whom correspondence should be addressed

Reports of successful treatment of ectopic pregnancies by administration of methotrexate have recently attracted a great deal of attention. This review summarizes the results of therapy with methotrexate in tubal pregnancy. Different technical approaches and pharmacological doses have been reported. These methods, however, present various problems, including the occurrence of toxicity, long therapeutic periods and treatment failure. With proper selection of patients, a success rate of ~ 90% has been achieved. Preliminary assessment of subsequent fertility provides promising results. However, the majority of the reports do not include controls.

Key words: methotrexate/tubal pregnancy


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