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Human Reproduction, Vol. 8, No. 5, pp. 674-677, 1993
© 1993 European Society of Human Reproduction and Embryology

other

High levels of immunoreactive endothelin-1 in human follicular fluids

S. Kamada1, T. Kubota, M. Taguchi and T. Aso

Department of Obstetrics and Gynaecology, Faculty of Medicine, Tokyo Medical and Dental University 1-5-45 Yushima, Bunkyo-ku, Tokyo 113, Japan

Correspondence: 1To whom correspondence should be addressed

Follicular fluids were obtained from 180 follicles of 15 women undergoing follicular aspiration for in-vitro fertilization. Follicular development was induced by a combination of buserelin acetate and human menopausal gonadotrophin. Endothelin-1 (ET-1) concentrations in human follicular fluids were determined by specific radioimmunoassay. ET-1-like immunoreactivity (ET-1-LI) ranged from 338 to 928 pg/ml. ET-1-LI concentrations in follicular fluids obtained from immature (< 15 mm) follicles were significantly higher than those from mature (15–25 mm) and post-mature (≥25 mm) follicles. No correlation was found between the concentration of ET-1-LI, on the one hand, and that of oestradiol, progesterone, testosterone, prolactin, luteinizing hormone, insulin-like growth factor-I, prostaglandin E2 or platelet activating factor on the other, in follicular fluids. However, a significant positive correlation was observed between ET-1-LI concentration and follicle stimulating hormone and IGF-II concentrations, respectively. These data suggest that the high concentration of ET-1 found in follicular fluids may play some physiological role in follicular development.

Key words: endothelin-1/follicular development/follicular fluid/IVF—embryo transfer/radioimmunoassay


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