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Human Reproduction, Vol. 8, No. 7, pp. 1001-1004, 1993
© 1993 European Society of Human Reproduction and Embryology

other

The relationship between body composition and plasma concentrations of exogenously administered urinary follicle stimulating hormone

V. Remorgida1, M. Giordano, P. Lanera, S. Costantini and L. de Cecco

Istituto di Ginecologia ed Ostetricia, Universitá di Genova Ospedale San Martino, Viale Benedetto XV, 16143 Genova, Italy

Correspondence: 1To whom correspondence should be addressed

The aim of this study was to evaluate the plasma absorption of i.m. administered exogenous urinary follicle stimulating hormone (FSH) in relation to body fatness, leanness and cell mass. Body composition was measured by means of bioelectrical impedance. An immunoradiometric assay was used to assess the concentration of exogenous FSH in blood in patients with a pharmacologically induced hypogonadotrophism who were undergoing ovulation induction for assisted reproduction. No correlation was found between body composition and the hormone concentration in blood. According to our results, the different requirements of gonadotrophin administration typically observed in patients of different weights are probably not related to different absorption and distribution of the drug.

Key words: body composition/menotrophins/ovulation induction


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