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Human Reproduction, Vol. 8, No. 7, pp. 1079-1082, 1993
© 1993 European Society of Human Reproduction and Embryology

other

The effects on in-vitro fertilization of autoantibodies to spermatozoa in subfertile men

S.V. Rajah1, J.M. Parslow, R.J. Howell and W.F. Hendry2

Departments of Gynaecology and Urology, St Bartholomew's Hospital London EC1A 7BE, UK

Correspondence: 2To whom correspondence should be addressed at: 149 Harley Street, London WIN 2DE, UK

Thirty-six infertile couples underwent treatment by in-vitro fertilization. In 16 couples (group 1) the male partner was positive for antisperm antibodies measured by direct mixed antiglobulin reaction, direct immunobead test, and serum and/or seminal plasma tray agglutination test. In 20 couples (group 2) the men had no such antibodies. Men with poor sperm motility were excluded. The female partners had no antisperm antibodies, and in the controls (group 2) infertility was due to a known female factor. The fertilization rate in couples without antisperm antibodies (group 2) was 72.7% compared to 50.5% when the men had antibodies. However, the pregnancy rate per embryo transfer was not significantly different in the two groups (46.1% in group 1, 33.3% in group 2). This indicates that antisperm antibodies in the male interfere with sperm —egg fusion and subsequent fertilization but once fertilization has occurred, the pregnancy rate remains the same.

Key words: antisperm antibodies/subfertile men/in-vitro fertilization

1Present address: Reproductive Medicine Unit, Withington Hospital, West Didsbury, Manchester M20 8LR, UK


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