Skip Navigation

This Article
Right arrow Full Text (PDF )
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (14)
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Anttila, L.
Right arrow Articles by Ruutiainen, K.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Anttila, L.
Right arrow Articles by Ruutiainen, K.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Human Reproduction, Vol. 8, No. 8, pp. 1179-1183, 1993
© 1993 European Society of Human Reproduction and Embryology

research-article

Endocrinology: Insulin hypersecretion together with high luteinizing hormone concentration augments androgen secretion in oral glucose tolerance test in women with polycystic ovarian disease

L. Anttila1, P. Koskinen2, T.-A. Jaatinen, R. Erkkola, K. Irjala2 and K. Ruutiainen

Department of Obstetrics and Gynaecology, Turku University Central Hospital Kiinamyllynkatu 4-8, SF-20520 Turku, Finland 2Central Laboratory, Turku University Central Hospital Kiinamyllynkatu 4-8, SF-20520 Turku, Finland

Correspondence: 1To whom correspondence should be addressed

Female hyperandrogenism is often associated with hyper-insulinaemia and insulin resistance. We evaluated the hormone responses in an oral glucose tolerance test to investigate the interactions of gonadotrophins, insulin, C-peptide and androgens in women with polycystic ovarian disease (PCOD). In 28 patients with ultrasonographically diagnosed PCOD, hyperinsulinaemia and insulin resistance were mainly associated with obesity. Both basal and cumulative sum of insulin to C-peptide ratios were high in obese subjects, suggesting decreasing hepatic removal of insulin caused by obesity. Nevertheless, in some lean PCOD women, despite normal fasting insulin concentrations, insulin hyper-secretion existed. The mean concentration of testosterone decreased significantly during the oral glucose tolerance test both in PCOD and control women, and of androstenedione in the PCOD patients only. However, an increase in androgen responses was found in a subgroup of PCOD patients, who had both elevated luteinizing hormone (LH) concentrations and hyperinsulinaemic response to oral glucose. In the remaining PCOD patients an inverse correlation between LH and insulin was found. The patients with hyperinsulinaemia together with LH hypersecretion may represent a subgroup of PCOD with deranged regulation of androgen secretion.

Key words: androgens/C-peptide/insulin/gonadotrophins/polycystic ovarian disease


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Hum ReprodHome page
M. Mikola, V. Hiilesmaa, M. Halttunen, L. Suhonen, and A. Tiitinen
Obstetric outcome in women with polycystic ovarian syndrome
Hum. Reprod., February 1, 2001; 16(2): 226 - 229.
[Abstract] [Full Text] [PDF]

Home page
 Endocr. Rev.Home page
L. Poretsky, N. A. Cataldo, Z. Rosenwaks, and L. C. Giudice
The Insulin-Related Ovarian Regulatory System in Health and Disease
Endocr. Rev., August 1, 1999; 20(4): 535 - 582.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
M.B. Tiras, R. Yalcin, V. Noyan, I. Maral, M. Yildirim, O. Dortlemez, and S. Daya
Alterations in cardiac flow parameters in patients with polycystic ovarian syndrome
Hum. Reprod., August 1, 1999; 14(8): 1949 - 1952.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
A.M. Fulghesu, F. Cucinelli, V. Pavone, F. Murgia, M. Guido, A. Caruso, S. Mancuso, and A. Lanzone
Changes in luteinizing hormone and insulin secretion in polycystic ovarian syndrome
Hum. Reprod., March 1, 1999; 14(3): 611 - 617.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.