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Human Reproduction, Vol. 8, No. 8, pp. 1293-1296, 1993
© 1993 European Society of Human Reproduction and Embryology

research-article

Pregnancy: Adverse effect of a homogeneous hyperechogenic endometrial sonographic pattern, despite adequate endometrial thickness on pregnancy rates following in-vitro fertilization

J.H. Check1, D. Lurie, C. Dietterich, C. Callan and A. Baker

The University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School at Camden, Cooper Hospital University Medical School at Camden, Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology & Infertility Camden, NJ, USA

Correspondence: 1To whom correspondence should be addressed at: 8002 E.Greentree Commons, Marlton, NJ 08053, USA

We have previously presented data to show that in patients who had in-vitro fertilization (IVF)—embryo transfer using ovarian stimulation involving the luteal phase leuprolide acetate—human menopausal gonadotrophin (HMG) regimen, poor pregnancy results ensued if either the endometrial thickness was < 10 mm or a homogeneous hyperechogenic sonograpic pattern was present immediately prior to taking a human chorionic gonadotrophin (HCG) injection. There were only 15 cases with this hyperechogenic type endometrium (and no pregnancies). The purpose of the present study was to evaluate the influence of a hyperechogenic endometrium when the endometrial thickess was ≥10 mm, in a more extensive series, in women having IVF—embryo transfer using the same ovarian stimulation regimen. A total of 273 consecutive cycles, where endometrial thickness was ≥10 mm, were evaluated (not including the 85 cycles previously reported). Of 22 patients with the hyperechogenic pattern, one achieved a chemical pregnancy ({beta}-HCG >500 mIU/ml) and none achieved clinical pregnancies (ultrasound confirmation). In contrast, 67 of 251 (26.7%) patients conceived with other echo patterns (x2 analysis = 5.9, df = 1, P = 0.01). These data thus confirm, in a larger series, the negative influence of this type of echo pattern on subsequent pregnancy rates following the luteal phase leuprolide acetate—HMG ovarian stimulation regimen.

Key words: endometrial echo pattern/homogeneous/hyperechogenic/in-vitro fertilization


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