Human Reproduction, Vol. 8, No. 9, pp. 1372-1375, 1993
© 1993 European Society of Human Reproduction and Embryology
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Endocrinology: Human chorionic gonadotrophin is a better luteal support than progesterone in ultrashort gonadotrophin-releasing hormone agonist/menotrophin in-vitro fertilization cycles
Department of Obstetrics & Gynaecology, Assaf Harofeh Medical Centre, Affiliated to Sackler School of Medicine Tel Aviv University, Israel
Correspondence: 1To whom correspondence should be addressed at: Department of Obstetrics & Gynaecology, Assaf Harofeh Medical Centre, Zerifin 70300, Israel
In an attempt to determine the best luteal support in in-vitro fertilization (IVF) cycles treated with gonadotrophin-releasing hormone agonist (GnRHa) and human menopausal gonadotrophin (HMG) by the ultrashort protocol, 60 patients were prospectively randomized for either i.m. progesterone or human chorionic gonadotrophin (HCG) luteal support. The two groups did not differ in the mean number of oocytes retrieved and embryos replaced, nor in the mean age of the patients and the amount of HMG used. HCG maintained higher levels of oestradiol and progesterone during the luteal phase. Conception rate was significantly higher in the HCG group. We conclude that HCG is superior to i.m. progesterone as luteal support in IVF cycles in which GnRHa is used in the ultrashort protocol.
Key words: gonadotrophin-releasing hormone agonist/human chorionic gonadotrophin/in-vitro fertilization/progesterone
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