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Human Reproduction, Vol. 8, No. 9, pp. 1426-1428, 1993
© 1993 European Society of Human Reproduction and Embryology

research-article

Infertility: Assessments of embryo transfer after in-vitro fertilization: effects of glyceryl trinitrate

Adel G. Shaker1, Richard Fleming, Mary E. Jamieson, Robert W.S. Yates and John R.T. Coutts

University Department of Obstetrics and Gynaecology, Royal Infirmary Glasgow G31 2ER, UK

Correspondence: 1To whom correspondence should be addressed

The role of embryo transfer and its associated difficulties on the outcome of human in-vitro fertilization (IVF) were examined using a standardized procedure and a scoring system (embryo transfer scores 1–5). This system was used to assess any effects of the smooth muscle relaxant glyceryl trinitrate (GTN) on embryo transfer. Patients (n = 120) were randomized in a double-blind manner at their first embryo transfer to receive sublingual GTN or placebo before the transfer. Retrospective analysis showed that higher pregnancy rates were associated with uncomplicated transfers (score 1; P < 0.01). The outcome measures included pregnancy rate, total time of cervical manipulation (embryo transfer time) and embryo transfer score. All pregnancies had a transfer score of 1 or 2, but no recorded parameter differentiated between pregnant or non-pregnant cycles, and GTN had no significant effect on any parameter.

Key words: embryo transfer/glyceryl trinitrate/in-vitro fertilization/pregnancy rate


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