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Human Reproduction, Vol. 8, No. suppl_2, pp. 13-17, 1993
© 1993 European Society of Human Reproduction and Embryology

Pulsatile release of gonadotrophin releasing hormone (GnRH) is an intrinsic property of GT1 GnRH neuronal cell lines

Richard I. Weiner1,3 and Gonzalo Martinez de La Escalera2

1 Reproductive Endocrinology Center, University of California San Francisco San Francisco, CA 94143, USA 2 Instituto de Investigaciones Biomedicas, National University of Mexico Mexico City, Mexico 04510

Correspondence: 3To whom correspondence should be addressed

The GT1-1 gonadotrophin releasing hormone (GnRH) cell line releases GnRH in a pulsatile fashion. This finding demonstrates that the generation and synchronization of GnRH pulses is an intrinsic property of GnRH neurons. It appears that propagated action potentials and a Ca2+-coupled secretory mechanism are necessary for pulsatile release. The secretion of GnRH from GT1, cells is stimulated by both norepinephrine and dopamine respectively via β1-adrenergic and D1-dopaminergic receptors. These findings provide new data for the understanding of the complex neuroendocrine regulation of luteinizing hormone.

Key words: GnRH/GT1 cell lines/hypothalamic neurons/neurotransmitters/pulsatile secretion


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