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Human Reproduction, Vol. 8, No. suppl_2, pp. 51-56, 1993
© 1993 European Society of Human Reproduction and Embryology

Characterization and regulation of pre-ovulatory secretion of gonadotrophin-releasing hormone

Suzanne M. Moenter1, Caraty Alain2, Michael N. Lehman3 and Fred J. Karsch1

1 Reproductive Sciences Program and Department of Physiology, University of Michigan 300 N.Ingalls Bldg, 11th Floor, Ann Arbor, MI 48109-0404, USA 2 Station de Physiologie de la Reproduction, Institut National de la Recherche Agronomique (A.C.) Nouzilly, France 3 Department of Anatomy and Cell Biology, University of Cincinnati , Cincinnati, OH, USA

Correspondence: 1To whom correspondence should be addressed

Using an elegant method for sampling of pituitary portal blood the secretory characteristics of gonadotrophin-releasing hormone (GnRH) during the oestradiol induced surge are studied. It is demonstrated that the neuroendocrine signal for ovulation in the ewe is a surge of GnRH released into the portal blood.

Key words: gonadotrophin-releasing hormone/luteinizing hormone/oestradiol/ovulation/sheep


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