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Human Reproduction, Vol. 8, No. suppl_2, pp. 62-65, 1993
© 1993 European Society of Human Reproduction and Embryology

Role of gonadotrophin releasing hormone secretory dynamics in the control of the human menstrual cycle

M. Filicori1, G. Cognigni, P. Dellai, R. Arnone, M. Sambataro, A. Falbo, R. Pecorari, F. Carbone and M.C. Meriggiola

Reproductive Endocrinology Centre, Department of Obstetrics and Gynaecology, University of Bologna Italy

Correspondence: 1To whom correspondence should be addressed at: Clinica Ostetrica e Ginecologica, Via Massarenti 13, 40138 Bologna, Italy

The pattern of episodic gonadotrophin releasing hormone (GnRH)-driven luteinizing hormone (LH) secretion changes dynamically across the human menstrual cycle. Adherence to a specific regimen of pulse amplitude and frequency is critical for normal ovulation, menstrual cyclicity and reproductive function. Derangements of episodic LH secretion are associated with anovulation. We have shown that in the human slowing of GnRH-induced LH pulses results in lower ovulatory rates and dysfunctions of the mid-cycle LH surge. This information is relevant for the understanding of the endocrine dynamics of the menstrual cycle both in normal and anovulatory subjects.

Key words: GnRH/LH surge/menstrual cycle/ovulation/pulsatile


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