Human Reproduction, Vol. 9, No. 12, pp. 2270-2277, 1994
© 1994 European Society of Human Reproduction and Embryology
research-article |
Immunology: CD56+ lymphoid cells in human first trimester pregnancy decidua as a source of novel transforming growth factor-
2-related immunosuppressive factors
2Departments of Medicine Hamilton, Ontario, Canada 3Obstetrics and Gynaecology and Pathology, McMaster University Hamilton, Ontario, Canada 4Department of Obstetrics and Gynaecology, Nuffield Department of Obstetrics and Gynaecology, John Radcliffe Hospital, Oxford University Oxford, UK 5Laboratory of Chemoprevention, NIH, Bethesda MD, USA
Correspondence: 1To whom correspondence should be addressed at: Room 3V39, McMaster University, 1200 Main Street West, Hamilton, Ontario, Canada L8N 3Z5
The lymphomyeloid cells isolated from normal first trimester pregnancy decidua may be separated into a CD56+ population of natural killer (NK)-lineage cells with the morphology of granulated lymphocytes, and a CD56– population which includes other cell types. Unlike CD56+ NK cells in peripheral blood, decidual CD56+ cells lack type III Fc receptors (CD16) and did not express significant levels of either type I FcR (CD64) or type II FcR (CDw32). By contrast to the decidual CD56– cells, CD56+ cells could release biologically active transforming growth factor (TGF)-
in vitro, detectable using an normal rat kidney fibroblast colony-forming assay. The CD56+ cells could be stained using an antibody specific for TGF-2, and similarly staining cells could be detected in intact biopsies of normal pregnancy decidua. Bioactive TGF- is known to suppress the generation of cytotoxic cells in vitro, and high performance liquid chromatography fractionation of supernatants conditioned by CD56+ but not CD56– cells contained reproducible peaks of immunosuppressive activity at 40–45 and 15–20 kDa, similar to the TGF-2 immunosuppressive activity in supernatants conditioned by unfractionated decidua.
Key words:
CD56+/lymphoid cells/decidua/immunosuppression/TGF-2
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