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Human Reproduction, Vol. 9, No. 2, pp. 200-208, 1994
© 1994 European Society of Human Reproduction and Embryology

other

Biochemical and immunohistochemical multiparametric analysis of steroid receptors and growth factor receptors in human normal endometrium in spontaneous cycles and after the induction of ovulation

J. Salat-Baroux1,, S. Romain2, S. Alvarez3, J.M. Antoine3, K. Kopp2, D. Raulais4, J.de Brux4 and P.M. Martin2

Service d'Obstérique et de Biologie de la Reproduction, Hospital Tenon 4 Rue de la Chine, Paris 20è 2Laboratoire de Cancérologie et Oncologie Biologique, Faculté de Médecine Nord, APM Marseille 3Institut de Pathologic, H⊚spital Tenon Paris 4U 118, INSERM Pr. Courtois, France

Correspondence: 1To whom correspondence should be addressed

This study was carried out with three aims: to assess the variations of receptors for {beta}-oestradiol and progesterone, and for epidermal growth factor (EGF), {alpha}-fibroblast growth factor (FGF) and {beta}-FGF, during a spontaneous cycle in normo-ovulatory patients, 2 days before, and 2 and 7 days after the day of ovulation; to compare the control group of patients with those given ovulation induction using a multiparametric approach; and to study the role of luteal supplementation with progesterone in two groups of patients treated by a luteinizing hormone-releasing hormone agonist plus human menopausal gonadotrophin. The results were assessed by biochemical analyses and by immunohisto-chemistry. In spontaneous cycles, a decrease in steroid receptors occurred during the luteal phase. There was an increase in EGF and EGF receptors which was induced by oestradiol secretion, and an increase during the luteal phase of {alpha}-FGF and {beta}-FGF, which are considered to be angiogenic factors. Comparisons between spontaneous and induced cycles showed a few variations in the endometrium but no differences were related to the type of ovulation induction.

Key words: endometrium/growth factors/ovulation induction/spontaneous cycles/steroid receptors


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