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Human Reproduction, Vol. 9, No. 2, pp. 209-213, 1994
© 1994 European Society of Human Reproduction and Embryology

other

Growth hormone co-treatment for ovulation induction may enhance conception in the co-treatment and succeeding cycles, in clonidine negative but not clonidine positive patients

Zeev Blumenfeld1,2, Martha Dirnfeld1, Yael Gonen1 and Haim Abramovici1

Reproductive Endocrinology and Infertility Section, Departments of Obstetrics and Gynaecology Haifa, 31096, Israel 1Rambam Medical Centre The Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology Haifa 31096, Israel 2Carmel Hospital, The Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology Haifa, 31096, Israel

Correspondence: 1To whom correspondence should be addressed at: Reproductive Endocrinology and Infertility Section, Rambam Medical Centre, The Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa 31096, Israel

To investigate the effect of co-treatment with growth hormone (GH) for ovulation induction with human menopausal gonadotrophins (HMG) on conception, we compared the pregnancy rate and response to co-treatment with GH versus HMG/human chorionic gonadotrophin (HCG) alone in a prospective, randomized, cross-over protocol of volation induction for either in-vivo or in-vitro fertilization (IVF). The main outcome measures were the amount of gonadotrophin used and conception. Co-treatment with GH was associated with a reduction of ~30% in gonadotrophin requirement. In 24 clonidine negative patients 14 pregnancies were achieved (58.3%) either in the GH/HMG/HCG cycle or in the succeeding one. GH co-treatment did not generate any pregnancy in eight clonidine positive patients. We conclude that growth hormone may increase the pregnancy rate when combined with HMG/HCG for ovulation induction, not only in the co-treatment cycle but also in the succeeding one. The beneficial, synergistic effect of GH co-treatment was detected in clonidine negative but not in clonidine positive infertile patients.

Key words: clonidine test/growth hormone co-treatment/ovulation induction/poor responders/unexplained infertility


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