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Human Reproduction, Vol. 9, No. 2, pp. 229-234, 1994
© 1994 European Society of Human Reproduction and Embryology

other

Oestrogen and progesterone do not regulate the expression of retinoic acid receptors and retinoid ‘X’ receptors in human endometrial stromal cells in vitro

M.Kumar Kumarendran1,3,6, C.Jane Matthews2, Mark D. Levasseur3, Andrew Prentice1,5, Eric J. Thomas4 and Christopher P.F. Redfern3,6

1Departments of Obstetrics & Gynaecology Coxford Road, Southampton SO9 4HA, UK 2Departments of Physiological Sciences Coxford Road, Southampton SO9 4HA, UK 3Departments of Medicine, Medical School, University of Newcastle Coxford Road, Southampton SO9 4HA, UK 4Department of Obstetrics & Gynaecology, University of Southampton, Princess Anne Hospital Coxford Road, Southampton SO9 4HA, UK

Correspondence: 6To whom correspondence should be addressed at: Medical Molecular Biology Group, Department of Medicine, 4th Floor, Cookson Building, Medical School, Newcastle upon Tyne NE2 4HH, UK

Elucidation of the gene structure for retinoic acid receptor-{beta} (RAR-{beta}) has suggested a potential role for oestrogen in regulating the expression of RAR-{beta}. We have previously shown that all three RAR types are expressed in human endometrial stromal cells in vitro and that RAR-{beta} expression is induced in response to retinoic acid. The aim of this study was to ask whether oestradiol and progesterone could play a part in regulating the expression of RARs in human endometrial stromal cells and to establish the patterns of expression of a related group of nuclear retinoid receptors, retinoid ‘X’ receptors (RXRs) and their potential for regulation by steroid hormones. The RAR expression patterns of endometrial stromal cells, grown in steroid-free medium, did not change in response to the presence of steroid hormones. Furthermore, the retinoic acid-mediated induction of RAR-{beta} was not affected by oestradiol or progesterone, and was dependent on the continued presence of retinoic acid. Of the three RXR types, only RXR-{alpha} was detectably expressed in stromal cells in vitro and the expression of RXR-{alpha} did not change in response to steroid hormones or retinoic acid. These data indicate that oestradiol and progesterone are not important in the regulation of RAR and RXR expression in human endometrial stromal cells.

Key words: endometrium/oestrogen/retinoic acid/retinoic acid receptors/RXR

5Present address: Department of Obstetrics & Gynaecology, University of Cambridge, Rosie Maternity Hospital, Cambridge CB2 2SW, UK


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